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Broad Institute Inc
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Image Search Results
Journal: Frontiers in Neuroscience
Article Title: Detection of differentially expressed genes in spatial transcriptomics data by spatial analysis of spatial transcriptomics: A novel method based on spatial statistics
doi: 10.3389/fnins.2022.1086168
Figure Lengend Snippet: Global Moran’s index revealing three spatial autocorrelation patterns. Clustered, z > 1.65 and P < 0.1; random, –1.65 < z < 1.65 and P > 0.1; dispersed, z < –1.65 and P < 0.1. ST, spatial transcriptomic; CI, confidence interval.
Article Snippet:
Techniques:
Journal: Frontiers in Neuroscience
Article Title: Detection of differentially expressed genes in spatial transcriptomics data by spatial analysis of spatial transcriptomics: A novel method based on spatial statistics
doi: 10.3389/fnins.2022.1086168
Figure Lengend Snippet: Differentially expressed genes (DEGs) in the different brain regions. (A) Brain region. ROI indicates sensorimotor cortex. (B) Yellow area indicates sensorimotor cortex in HE images. (C) Arpp19 of ST map. (D) Hotspot of Arpp19 . (E) DEGs in the sensorimotor cortex. Ratio = The number of H-H spots in sensorimotor cortex/The total number of spots in the section. (F) Septicity of DEGs in the sensorimotor cortex. Ratio = The number of H-H spots in each region/The total number of H-H spots. (G) Marker genes of each brain region. ST, spatial transcriptomic.
Article Snippet:
Techniques: Marker
Journal: Frontiers in Neuroscience
Article Title: Detection of differentially expressed genes in spatial transcriptomics data by spatial analysis of spatial transcriptomics: A novel method based on spatial statistics
doi: 10.3389/fnins.2022.1086168
Figure Lengend Snippet: Downregulated DEGs revealed by saSpatial. (A) Bubble plots of top20 DEGs. P -values are indicated by circle size; scale adjacent to the plot. The rate difference are indicated by color. NC, normal control. P, penumbra. Typical DEGs of (B) ischemic core and (C) penumbra. N = 3. ST, spatial transcriptomic; CI, confidence interval.
Article Snippet:
Techniques: Control
Journal: Frontiers in Neuroscience
Article Title: Detection of differentially expressed genes in spatial transcriptomics data by spatial analysis of spatial transcriptomics: A novel method based on spatial statistics
doi: 10.3389/fnins.2022.1086168
Figure Lengend Snippet: Differentially expressed genes (DEGs) in the cortex layers. (A) Top 3 DEGs in the layers. (B) Typical DEGs. ST, spatial transcriptomic.
Article Snippet:
Techniques:
Journal: Frontiers in Neuroscience
Article Title: Detection of differentially expressed genes in spatial transcriptomics data by spatial analysis of spatial transcriptomics: A novel method based on spatial statistics
doi: 10.3389/fnins.2022.1086168
Figure Lengend Snippet: Heterogenicity of DEGs within the ischemic cortex. (A) Six layers of cortex in the ischemic cortex. (B) Typical DEGs. (C) ST map and Hotspot of typical DEGs. ST, spatial transcriptomic.
Article Snippet:
Techniques:
Journal: Frontiers in Physiology
Article Title: Long-term stimulation with alternating electric fields modulates the differentiation and mineralization of human pre-osteoblasts
doi: 10.3389/fphys.2022.965181
Figure Lengend Snippet: Results of the transcriptome analysis. (A) Heatmap of all genes with higher/lower fold change value than 1/-1 (log2), compared between unstimulated control cells and HEF stimulated cells after 7 and 28 days. (B) Heatmap of top 10 genes with highest and lowest fold changes (log2) each day. (C) Pathways influenced by the electric stimulation. Each node (circle) represents a distinct molecular or biological function, and edges (green lines) represent the number of overlapping genes, determined using a similarity coefficient . Yellow and orange circles represent upregulated molecular or biological functions after 7 (yellow) and 28 days (orange) of HEF stimulation, respectively. Green and blue circles represent downregulated molecular or biological functions after 7 (green) and 28 days (blue) of HEF stimulation, respectively.
Article Snippet: In the
Techniques: Control